Chlorpromazine (THORAZINE) and promethazine (PHENERGAN) may prolong the QT interval.

Do all antiemetics cause QT prolongation?

QT interval prolongation is a common side effect shared among the most effective antiemetic classes. The risk of QT prolongation is exacerbated by electrolyte abnormalities observed in patients with ongoing emesis, particularly hypokalemia.

Does Cyclizine cause QT prolongation?

Cyclizine would be the anti-emetic of choice in this patient as it has not been associated with QT prolongation.

Does metoclopramide prolong QT?

Conclusions: Metoclopramide administration increases the QT/RR slope and QT variance. These findings may partly explain the underlying mechanism of ventricular arrhythmias associated with metoclopramide.

Does prochlorperazine cause QT prolongation?

Prochlorperazine may increase the risk of QT interval prolongation. Best to avoid use with other potentially QT-prolonging medications. Combination of prochlorperazine with SSRI/SNRI, ondansetron, metoclopramide, promethazine, isoflurane, and sevoflurane may increase the risk of QT prolongation.

Long QT Syndrome and Torsades de Pointes, Animation

30 related questions found

Which antiemetic does not cause QT prolongation?

Both ondansetron and granisetron prolong the QT interval when administered intravenously at doses over 8 mg and 10 micrograms/kg respectively. However, there have been no reports of QT prolongation following oral administration. Palonosetron and tropisetron are not associated with QT prolongation.

Is amiodarone contraindicated in torsades?

cessation of all QT-prolonging medications

Evidence regarding which drugs cause torsades is extremely murky. In some cases it seems that drugs have been incorrectly maligned (e.g. azithromycin, olanzapine).

Does Thorazine cause QT prolongation?

This is consistent with results of other published reports. Chlorpromazine is considered a high-risk drug for QTc prolongation, with one study finding an increased relative risk of 1.37 (95% CI 1.14-1.64).

Does Zofran prolong QT?

ECG changes including QT interval prolongation have been observed in patients receiving ondansetron. In addition, Torsade de Pointes, an abnormal, potentially fatal, heart rhythm, has been reported in some patients receiving ondansetron. The use of a single 32 mg intravenous dose of ondansetron should be avoided.

Does Decadron prolong QT?

Treatment with high-dose dexamethasone was repeatedly associated with a decrease in the QT interval that was reversible upon cessation of treatment.

Do beta blockers prolong QT?

Beta-blockers have heart-rate-dependent effects on the QT and QTc intervals in LQTS. They appear to increase the QT and QTc intervals at slower heart rates and shorten them at faster heart rates during exercise.

Does metoprolol prolong QT interval?

Conclusions/interpretation: This study is the first to address the QTc interval and QTc dispersion in Type 1 diabetic patients treated with metoprolol. Beta blocker treatment caused a decrease in QTc interval but no change in QTc dispersion.

Does Keppra cause QT prolongation?

The prolongation of QT interval after increasing the levetir- acetam dose was unexpected since levetiracetam has been one of the AEDs thought to have a minimal effect on QT intervals. Siniscalchi and coworkers reported an increase of only about 25 ms in QTc in post-stroke patients treated with levetiracetam [2].

Does amlodipine prolong QT interval?

Despite similar BP-lowering effects, the direct renin inhibitor aliskiren, but not the calcium channel blocker (CCB) amlodipine, decreased the duration of the QT interval in these patients. Therefore, pharmacotherapies with similar effects on hypertension will not exert identical effects on cardiac repolarization.

Is Zofran a dopamine antagonist?

Zofran and Reglan belong to different antiemetic drug classes. Zofran is a selective 5-HT3 receptor antagonist and Reglan is a dopamine antagonist.

Is Zofran a prokinetic?

Brand names for ondansetron include Zofran, Zofran ODT, and Zuplenz. Brand names for metoclopramide include Reglan and Metozolv ODT. Ondansetron and metoclopramide belong to different drug classes. Ondansetron is an anti-nausea medication and metoclopramide is a "prokinetic" drug.

Does oral Zofran cause QT prolongation?

- ECG changes including QT interval prolongation have been seen in patients receiving Zofran (ondansetron). In addition, Torsade de Pointes, an abnormal heart rhythm, has been reported in some patients receiving ondansetron.

Is Zofran bad for your heart?

Abnormal Heart Rhythms Zofran can cause QT interval prolongation and a potentially fatal heart rhythm called torsades de pointes.

When should you not take Zofran?

You should not use Zofran if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Zofran orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

Does ceftriaxone cause QT prolongation?

Introduction: Macrolides, linezolid, imipenem-cilastatin, fluoroquinolones, penicillin combinations, and ceftriaxone are known to be associated with Torsades de pointes/QT prolongation (TdP/QTP).

Does Remeron cause QT prolongation?

QT prolongation and torsades de pointes have been reported with the use of REMERON^® / REMERON RD^® (mirtazapine). Most cases occurred in association with drug overdose or in patients with other risk factors for QT prolongation, including concomitant use of QT prolonging medications.

Does azithromycin cause QT prolongation?

Azithromycin exposure has been reported to increase the risk of QT prolongation and cardiovascular death. However, findings on the association between azithromycin and cardiovascular death are controversial, and azithromycin is still used in actual practice.

Can amiodarone cause torsades?

4 Amiodarone is presumed to have a low incidence of drug-induced torsades de pointes (TdP) with an incidence of <0.5%.

Is amiodarone a calcium channel blocker?

Amiodarone possesses multiple pharmacologic properties, including peripheral and coronary vasodilatation, negative inotropy, and negative chronotropic and dromotropic effects. These properties are shared by the group of drugs termed calcium channel blockers.

Is amiodarone a beta blocker?

Amiodarone is a coronary and peripheral vasodilator (1). Metoprolol is a selective beta1-blocker and exerts a slight vasoconstrictor effect on coronary arteries due to its lack of beta2 stimulation (1).